Gravity: Blood and fluids naturally tend to accumulate more easily in the lower limbs.
Circulation: The liver plays a fundamental role in protein synthesis and in regulating pressure within the portal vein. When liver function decreases, blood flow in the legs can be affected.
Metabolism: The liver produces proteins—especially albumin—that help keep fluids inside the blood vessels. When albumin levels decrease, fluid can leak into the surrounding tissues, causing swelling.
Detoxification: When the liver cannot properly filter toxins, skin reactions such as itching or changes in skin color may occur.
